Perillylalcohol(POH)isamonoterpenewithanticarcinogenicandantitumoractivityinmurinetumormodels.Putativemechanismsofactionincludeactivationofthetransforminggrowthfactorbetapathwayand/orinhibitionofp21rassignaling,leadingtodifferentiationorapoptosis.
紫苏醇是一个在小鼠肿瘤模型中具有抗癌、抗肿瘤活性的单萜。假定的作用机制包括激活生长因子β通路和/或抑制ras信号，以导致分化或凋亡。
InthisPhaseItrial,17patientstookPOHp.o.threetimesdailyfor14daysofeach28-daycycle.ThestartingdoseofPOHwasmg/m2/dose,withescalationstoandmg/m2/doseinsubsequentcohorts.Chronicnauseaandfatigueweredose-limitingtoxiceffectsatmg/m2.Grade1-2hypokalemiawas从事皮肤病白癜风治疗白癜风治疗药物
